Visitors traveling on I-25 should take Exit 188 B and turn south on Poplar, driving toward Casper Mountain. Turn right at Collins Street and follow to the museum entrance located at the intersection of Collins and Wyoming Blvd.
Visitors to Casper arriving via Highway 220 should turn left on Wyoming Blvd. The very next stop light is the intersection of Wyoming Blvd. and Collins Street; turn left at this light into the museum entrance.
Visitors arriving in Casper via Highways 20/26 should turn right at Wyoming Blvd. Follow this road until you cross the North Platte River, and turn right at the intersection of Wyoming and Collins Street into the museum entrance.